Skeletal Muscle Regenerative Engineering
نویسندگان
چکیده
منابع مشابه
Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells.
Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main prope...
متن کاملTurning terminally differentiated skeletal muscle cells into regenerative progenitors
The ability to repeatedly regenerate limbs during the entire lifespan of an animal is restricted to certain salamander species among vertebrates. This ability involves dedifferentiation of post-mitotic cells into progenitors that in turn form new structures. A long-term enigma has been how injury leads to dedifferentiation. Here we show that skeletal muscle dedifferentiation during newt limb re...
متن کاملGrowth Factors for Skeletal Muscle Tissue Engineering.
Tissue-engineered skeletal muscle holds promise as a source of graft tissue for repair of volumetric muscle loss and as a model system for pharmaceutical testing. To reach this potential, engineered tissues must advance past the neonatal phenotype that characterizes the current state of the art. In this review, we describe native skeletal muscle development and identify important growth factors...
متن کاملTissue engineering for skeletal muscle regeneration.
Stem cells and regenerative medicine have obtained a remarkable consent from the scientific community for their promising ability to recover aged, injured and diseased tissue. However, despite the noteworthy potential, hurdles currently hinder their use and clinical application: cell survival, immune response, tissue engraftment and efficient differentiation. Hence a new interdisciplinary scien...
متن کاملAdvances in skeletal muscle tissue engineering.
Skeletal muscle tissue engineering is a promising interdisciplinary specialty which aims at the reconstruction of skeletal muscle loss caused by traumatic injury congenital defects or tumor ablations. Due to the difficulty in procuring donor tissue, the possibilities for alternative treatment like autologous grafting (e.g. muscle flaps) are limited. This process also presents consistent problem...
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ژورنال
عنوان ژورنال: Regenerative Engineering and Translational Medicine
سال: 2019
ISSN: 2364-4133,2364-4141
DOI: 10.1007/s40883-019-00102-9